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                您當前位置:網站首頁 >> 醫藥新聞 >> 行業動態 >> 默克、輝瑞與 BioXcel 在胰腺癌領域達成合作
               
               
              默克、輝瑞與 BioXcel 在胰腺癌領域達成合作
              2019-03-07 13:05:30 來源:丁香園 瀏覽:2434

              PharmaTimes 于 3 月 5 日報道,BioXcel 醫療宣布德國默克和輝瑞與 Nektar 醫療在臨床試驗方面達成合作,旨在評價一種用于胰腺癌的新型三藥組合療法。這次的合作包括將 Bavencio(avelumab)、BXCL701 和 NKTR-214 作為一種潛在的組合療法用于胰腺癌。根據合作條款,BioXcel 負責啟動及管理臨床試驗,德國默克與輝瑞提供檢查點抑制劑免疫療法 Bavencio。Nektar 將提供 NKTR-214。

              Bavencio 是一種人類抗程序化死亡配體,是默克公司和輝瑞公司共同開發的一種全人單克隆抗體,用于免疫治療,其最初是用于治療非小細胞肺癌。Nektar 醫療首席科學官 Zalevsky 表示:「我們認為,有必要同時多維度靶向免疫系統,以解決胰腺癌等難以治療的腫瘤細胞生長背后的多種病因。」

              他繼續表示:「BXCL701、NKTR-214 和 Bavencio 三種實驗性藥物組合方案旨在利用多種作用機制,以更好地對抗胰腺癌,同時潛在地產生長期的癌癥免疫。我們很高興能與 BioXcel 以及默克公司和輝瑞公司在這個項目上進行合作。」美國 FDA 已經加速批準 Bavencio 用于治療 12 歲以上的轉移性梅克爾細胞癌(mMCC)成人和兒童患者,以及治療局部晚期或轉移性尿路上皮癌(mUC)患者。

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