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              MHRA 稱卡比馬唑與先天畸形風險增加有關
              2019-02-26 09:47:51 來源:丁香園 瀏覽:2293

              近日,英國藥品和保健產品監管機構(MHRA)發布藥物安全更新警告,指出卡比馬唑與先天性畸形風險增加有關,并敦促有生育能力的女性在接受該藥物治療期間使用有效的避孕措施。

              該藥已被批準用于治療甲狀腺功能亢進,孕婦甲狀腺功能亢進的充分治療通常可以預防嚴重的孕產婦并發癥,但是研究發現卡比馬唑可穿過胎盤屏障并導致畸形,包括頭部皮膚缺損、顱面畸形、腹壁和胃腸道缺陷以及室間隔缺損等。

              甲狀腺功能亢進是妊娠期間最常見內分泌疾病之一。0.1% 到 0.4% 孕婦合并甲狀腺功能亢進癥。抗甲狀腺藥物是孕婦甲狀腺功能亢進癥的首選治療方法,現有抗甲狀腺藥物以硫代酰胺類為主,包括丙硫氧嘧啶、甲巰咪唑和卡比馬唑等。


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