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                您當前位置:網站首頁 >> 醫藥新聞 >> 新藥上市 >> 2012年6月FDA批準上市新型減肥藥綠卡色林Lorcaserin Hydrochloride
               
               
              2012年6月FDA批準上市新型減肥藥綠卡色林Lorcaserin Hydrochloride
              2012-07-02 08:33:14 來源:有機化學網 瀏覽:5972
              美國食品和藥物管理局27日批準商品名為Belviq的減肥藥上市,這是該局1999年以來首次批準新減肥藥上市。

                這種藥物的主要成分是綠卡色林鹽酸鹽,適用于身體質量指數(BMI)超過27的成年超重或肥胖者,且他們至少患高血壓、Ⅱ型糖尿病和高膽固醇等與超重相關疾病中的一種。服藥者須同時節食并鍛煉才有望獲得較理想的減肥效果。

                身體質量指數是國際上衡量人體胖瘦程度以及是否健康的一個常用指標,其計算方法是體重(千克)除以身高(米)的平方,超過25為超重,30以上則屬肥胖。

                這種藥物能夠激活服用者大腦內的5-羥色胺2C受體,幫助他們在進食較少的情況下就產生吃飽的感覺,從而起到減肥作用。其安全性和有效性在近8000名超重或肥胖者參與的3項臨床試驗中得到驗證。

                在這些試驗中,所有參與者均減少日常熱量攝入并輔以鍛煉,部分參與者服藥,另一部分則服用安慰劑。一年后的數據顯示,服藥者體重減輕約6%,服用安慰劑者體重減少2%至3%。試驗還顯示,其副作用主要有頭痛、疲勞、口干等,糖尿病患者還容易引起低血糖。

                這種藥物由瑞士阿雷納制藥公司生產。藥管局藥品評估和研究中心主任珍妮特·伍德科克當天說,肥胖是一個重要公共衛生關切,這種藥物獲得批準為美國肥胖者和超重者提供了一種新的治療選擇。

                美國疾病控制和預防中心上月發布預測報告稱,按發展趨勢,到2030年美國肥胖人口的比例將由目前的約三分之一上升至42%。

              中文名稱:
              綠卡色林鹽酸鹽
              英文名稱:
              Lorcaserin hydrochloride
              Cas#:
              846589-98-8
              含量:
              98%
              結構式:

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