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              2011年8月FDA批準肺癌新藥 (crizotinib)
              2011-10-06 19:51:14 來源:有機化學網 瀏覽:8745

                美國輝瑞公司治療肺癌的新藥XALKORI (crizotinib)膠囊獲得美國食品藥品管理局(FDA)批準,這是第一個對間變性淋巴瘤激酶 (ALK)進行靶向治療的藥品,可用于治療ALK陽性的局部晚期或轉移的非小細胞肺癌。

                據悉,該藥是第一個也是目前唯一一個用于治療局部晚期或轉移的ALK陽性非小細胞肺癌的新藥,也是近6年來美國FDA批準的第一個治療肺癌的新藥。XALKORI證明了分子標志物檢測在非小細胞肺癌中的重要性,成為個體化治療藥物研發的新里程碑,在特定的非小細胞肺癌人群中有顯著的客觀緩解率。

              Chinese Name: PF-02341066; 3-[(R)-1-(2,6-二氯-3-氟苯基)乙氧基]-5-[1-(哌啶-4-基)-1H-吡唑-4-基]吡啶-2-胺
              CAS Number: 877399-52-5
              Synonyms: 3-[(1R)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]pyridin-2-amine; PF 2341066
              Formula: C21H22Cl2FN5O 
              Molecular Weight: 450.34

               

               

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