<form id="p33rt"></form>

    <address id="p33rt"></address>
    <address id="p33rt"><nobr id="p33rt"><menuitem id="p33rt"></menuitem></nobr></address>

        <address id="p33rt"></address>

          <address id="p33rt"></address>

            <address id="p33rt"><form id="p33rt"><meter id="p33rt"></meter></form></address>

              <address id="p33rt"><listing id="p33rt"><meter id="p33rt"></meter></listing></address>

              有機化學人才網 | 最新人才 | 最新職位 | 技術交易 | 藥物合成 |
                 
              全站搜索: |
                您當前位置:網站首頁 >> 藥物合成路線圖解
               

              藥物詳細合成路線

              Name Resveratrol;trans-Resveratrol;SRT501;184072
              Chemical Name 3,4,5-Trihydroxy-trans-stilbene
                    (E)-5-(4-Hydroxystyryl)benzene-1,3-diol
                    5-[(E)-2-(4-Hydroxyphenyl)vinyl]benzene-1,3-diol
              CAS 501-36-0
              Related CAS
              Formula C14H12O3
              Structure
              Formula Weight 228.24994
              Stage II 期臨床
              Company National Cancer Institute (Not Determined)
              Activity/Mechanism Anti-Herpes Virus Drugs, ANTIINFECTIVE THERAPY, Antiviral Drugs, CARDIOVASCULAR DRUGS, Chemoprotective Agents, ONCOLYTIC DRUGS, Treatment of Disorders of the Coronary Arteries and Atherosclerosis, Apoptosis Inducers, Cyclooxygenase-1 Inhibitors, Lipid Peroxidation Inhibitors
              Syn. Route 3
              Route 1
              the reaction of 3,5-dihydroxybenzoic acid (i) with bn-br, k2co3 and 18-crown-6 in refluxing acetone gives 3,5-bis(benzyloxy)benzoic acid (ii), which is reduced with lialh4 in ethyl ether to yield the corresponding benzyl alcohol (iii). the reaction of (iii) with pbr3 in ethyl ether/pyridine affords the benzyl bromide (iv), which is treated with triisopropyl phosphite (v) at 140-150 c to provide the phosphonate (vi). the condensation of (vi) with 4-benzyloxybenzaldehyde (vii) by means of naome in dmf gives (e)-3,4,5-tris(benzyloxy)stilbene (viii), which is finally debenzylated by treatment with bbr3 in dichloromethane.alternatively, the synthesis of the target product can be performed by first condensation of 3,5-dimethoxybenzoyl chloride (ix) with 4-acetoxystyrene (x) by means of palladium(ii) acetate and et3n in p-xylene to yield (e)-4-acetoxy-3,5-dimethoxystilbene (xi), whose acetoxy group is subjected to saponification either with naome or with k2co3 in thf/h2o/meoh and whose methoxy groups are cleaved by means of bbr3 in ch2cl2.
              List of intermediates No.
              3,4-dimethoxy-2-nitrobenzoic acid (i)
              3-chloro-2-pentanone (ii)
              n-methyl-n-(2-phenyl-2-[[2-(trimethylsilyl)ethoxy]methyl]-4-pentenyl)benzenesulfonamide (x)
              (3s,4r)-4-(4-chlorophenyl)-1-methyl-3-piperidinecarboxylic acid (vii)
              7-[[amino(imino)methyl]amino]heptanamide (v)
              2,2-difluoro-2-(2-pyridinyl)ethyl trifluoromethanesulfonate (iii)
              2,2-difluoro-2-(2-pyridinyl)ethyl azide; 2-(2-azido-1,1-difluoroethyl)pyridine (iv)
              2-(2-azido-1,1-difluoroethyl)-1-pyridiniumolate (vi)
              2-(2-amino-1,1-difluoroethyl)-1-pyridiniumolate (viii)
              ethyl 2-[3-bromo-2-oxo-1(2h)-pyrazinyl]acetate (ix)
              2-(2-{[4-(2-ethoxy-2-oxoethyl)-3-oxo-3,4-dihydro-2-pyrazinyl]amino}-1,1-difluoroethyl)-1-pyridiniumolate (xi)
              Reference 1:
                  meredith, e.; andrus, m. (brigham young university); synthesis of resveratrol. wo 0160774 .

              Route 2
              the reaction of 3,5-dihydroxybenzaldehyde (i) with tbdms-cl gives the disilylated aldehyde (ii), which by a wittig condensation with methylenetriphenylphosphorane (iii) yields the 3,5-dihydroxystyrene (iv). the reaction of (iv) with acetic anhydride and pyridine affords 3,5-diacetoxystyrene (v), which was submitted to a heck condensation with 4-acetoxyiodobenzene (vi) by means of pd(oac)2 and pph3 in hot acetonitrile to provide 3,4,5-triacetopxy-(e)-stilbene (vii). finally, this compound is deacetylated by means of naome in thf/methanol to furnish the target resveratrol.
              List of intermediates No.
              benzyl ethyl[1-(4-[methyl(phenylsulfonyl)amino]-3-phenyl-3-[[2-(trimethylsilyl)ethoxy]methyl]butyl)-4-piperidinyl]carbamate (iii)
              Reference 1:
                  guiso, m.; et al.; a new efficient resveratrol synthesis. tetrahedron lett 2002, 43, 4, 597.

              Route 3
              the reaction of 4-methoxyphenyl iodide (i) with trimethylvinyllsilane (ii) and 3,5-dimethoxyphenyl iodide (iii) by means of pd(dba)2, kf, tetrabutylammonium chloride (tbac) and k2co3 in toluene gives the trimethoxystilbene (iv), which is finally demethylated by reaction with bcl3 and tetrabutylammonium iodide (tbai) in dichloromethane to afford the target resveratrol.
              List of intermediates No.
              ethyl 3-[4-(acetoxy)-3,3-dimethyl-2-oxo-1,2,3,4-tetrahydro-6-quinolinyl]propanoate (i)
              Reference 1:
                  jeffery, t.; ferber, b.; one-pot palladium-catalyzed highly chemo-, regio-, and stereoselective synthesis of trans-stilbene derivatives. a concise and convenient synthesis of resveratrol. tetrahedron lett 2003, 44, 1, 193.

              來源:藥化網

              作者:藥化小編

              摘要:本文合成路線介紹的是藥物中文名白藜蘆醇;英文名Resveratrol;trans-Resveratrol;SRT501;184072;CAS[501-36-0]

               
              推薦VIP企業
              無錫景耀生物科技有限公司
              杭州盧普生物科技有限公司
              寧波賽倫化工有限公司
              蘇州昊賽生物科技有限公司
              北京嘉盛揚醫藥科技有限公司
              上海澤涵生物醫藥科技有限公司
              河北固安三利化工公司
              鄭州凱普瑞生物技術有限公司
              上海藥谷藥業有限公司
              蘭州康寓信生物科技有限公司
              湖北朗昕生化藥業有限公司
              武漢福鑫化工有限公司
              嘉興市英南化工有限公司
              蘇州迪飛醫藥科技有限公司
              唐山盛源澤興化工有限公司
              上海盛中醫藥化工有限公司
              連云港天和化學有限公司
              南京晨瑞醫藥科技有限公司
              南京蘇如化工有限公司
              常州瑞盛化工有限公司
              熱門文章
              四川省2018年計劃抽檢24種
              華東地區醋酐市場行情暫穩
              江蘇地區順酐市場行情整理
              華南地區順酐市場行情整理
              中國化工并購先正達獲商務部批準
              山東地區異丙醇市場行情弱勢整理
              山東地區甲醛行情持穩
              山西地區甲醇市場局部走跌
              華南地區BDO市場行情暫行平穩
              華東地區BDO市場商談暫穩
              華北地區丁二烯市場報盤下滑
              山東地區二氯甲烷市場價格暫穩
              江蘇省農委統一負責全省農藥監督
              華中地區MTBE行情平穩
              山東環氧丙烷市場消化整理
              山東地區二氯甲烷市場價格下調
              山東地區苯酚市場市場繼續走低
              中國的吡唑醚菌酯如何具備全球優
              江蘇地區二氯甲烷價格暫穩
              專利殺菌劑fluindapyr
               友情鏈接
              有機化學人才網  
              首頁 | 廣告服務 | 建站服務 | 關于我們 | 聯系我們 | 版權聲明
              极速3D极速3D平台极速3D主页极速3D网站极速3D官网极速3D娱乐极速3D开户极速3D注册极速3D是真的吗极速3D登入极速3D快三极速3D时时彩极速3D手机app下载极速3D开奖 www.6623f.com | www.8547d.com | www.yh0789.com | www.23800b.com | www.c71.cc | www.64566m.com | www.tyc11678.com | www.jinsha759.com | www.jyh3288.com | www.99929v.com | www.jyh3188.com | www.1123zz.com | www.ljw037.com | www.56655s.com | www.lehu7188.com | www.wlc24.com | www.7d987.com | www.80800c.com | www.yh888e.com | www.43436f.com | www.62388i.com | www.edb666.com | www.91055q.com | www.hk0188.com | www.750790.com | www.535666e.com | www.586005.com | www.djcp004.com | www.87668l.com | www.21202p.com | www.3890s.com | www.64566m.com | www.15934393943.com | www.hg345i.com | www.tyc350.com | www.350a2.vip | www.35655l.com | www.198788.com | www.901582.com | www.540577.com | www.50732u.com | www.9155g.cc | www.37377r.com | www.1227q.com | www.p2718.com | www.3978d.com | www.cp7777p.com | www.129177.com | www.27280.cc | www.078xpj.com | www.pj7686.com | www.yd7891.com | www.586960.com | www.60007c.com | www.3479n.com | www.383899.com | www.7383y.com | www.12618822.com | www.952856.com | www.86267t.com | www.2109q.com | www.longhanlin.com | www.888877q.com | www.065061.com | www.834918.com | www.77801z.com | www.588yc.com | www.feicai0349.com | www.88850j.com | www.900778.com | www.177584.com | www.8fk.com | www.8999l.com | www.8145222.com | www.689631.com | www.49956f.com | www.18275660018.com | www.0289r.com | www.849749.com | www.81233n.com | www.hx6694.com | www.qile398.com | www.dxcp2222.com | www.214656.com | www.cai002.vip | www.u52266.com | www.59199q.com | www.117015.com | www.7fk.com | www.pj7198.com | www.740090.com | www.389144.com | www.rrle1.com | www.s76138.com | www.131hk.com | www.07163v.com | www.954321q.com | www.6321444.com | www.86087u.com | www.22jbs.net | www.wb399.com | www.812680.com | www.6598vip.com | www.244646.com | www.7894a.com | www.ac3177.com | www.1881885.com | www.wap.8d-app.com | www.257660.com | www.88899zz.com | www.sjgc2.com | www.891477.com | www.lebet98.com | www.65707x.com | www.3775.com | www.ff2355.com | www.550806.com | www.81866q.com | www.078wy.com | www.931786.com | www.laohupt6.com | www.66ffo.com | www.13249.com | www.vip7996.com | www.00840w.com | www.940999.com | www.h88968.com | www.16878j.com | www.554ms3122u.com | www.dw8885.com | www.80065z.com | www.01885h.com | www.7860nn.com | www.178387.com | www.11437.cm | www.3843208.com | www.61655t.com | www.00889.com | www.hj3330.com | www.12455t.com | www.727959gg.com | www.041234z.com | www.bxcp3.com | www.622105.com | www.62388z.com | www.143546.com | www.97655b.com | www.88837h.com | www.83335u.com | www.12455k.com | www.918681.com | www.2324bbb.com | www.76055n.com | www.316530.com | www.hjdc2002.vip | www.8666h.com | www.565hc.com | www.558423.com | www.98644.com | www.25288o.com | www.07163t.com | www.766464.com | www.399353.com | www.38200g.com | www.36166d.com | www.890402.com | www.98777z.com | www.fh9678.com | www.930xj.com | www.558402.com | www.3456200.com | www.fu599.com | www.18388773738.com | www.88266b.com | www.49009c.com | www.90.gg | www.huangjia70.com | www.8000hc.com | www.303470.com | www.ky1001.com | www.yh3386.com | www.0096bb.com | www.32123g.com | www.324577.com | www.04343.com | www.math.random | www.77009d.com | www.8839r.com | www.373553.com | www.551666.com | www.p2718.com | www.887766yh.com | www.1494555.com | www.9889hc.com | www.77114r.com | www.hcw823.com | www.45689.com | www.81866b.com | www.22557u.com | www.9321z.com | www.50024s.com | www.224344.com | www.811675.com | www.7384ppp.com | www.159666f.com | www.s2297.com | www.334455yh.com | www.k34348.com | www.2349005.com | www.063wy.com | www.36166t.com | www.435050.com | www.924570.com | www.1385.com | www.hg2020c.com | www.37570s.com | www.6625666.com | www.2019k.cc | www.hg345s.com | www.1039664743.com | www.le53.com | www.528qx.com | www.5484c.com | www.50064i.com | www.332902.com | www.739233.com | www.9605555.com | www.242266.com | www.hf5665.com | www.30007m.com | www.pj09061.com | www.455a.cc | www.long031.com | www.ww.pz77.com | www.8520b.com | www.hg0555g.com | www.ch1018.com | www.6cpb.com | www.84gcw.com | www.9356l.com | www.71233s.com | www.33598s.com | www.79520c.com | www.090392.com | www.rcw321.com | www.299695.com | www.514033.com | www.560103.com | www.560692.com | www.403489.com | www.534554.com | www.407873.com | www.382780.com | www.314877.com | www.202403.com | www.86267a.com | www.51515i.com | www.07163o.com | www.21202w.com | www.10113.com | www.3890p.com | www.ai772.com | www.cp208.com | www.sb3005.com | www.jsc586.com | www.h88962.com | www.qifa615.com | www.38135v.com | www.88850w.com | www.92288.com | www.ctxcp10.com | www.xjs8002.com | www.743.cc | www.702309.com | www.hcw332.com | www.84499b.com | www.50074b.com | www.3478y.cc | www.4647cc.net | www.111cp9.com | www.lehu287.com | www.75505b.com | www.50bbb.net | www.44p1.cc | www.48123a.com | www.xinyc3.com | www.193006.com | www.50732x.com | www.5086v.com | www.h7177.com | www.33vs33.com | www.1484kk.com | www.522557.com | www.82ms3122r.com | www.767397.com | www.bxcp3.com | www.39957c.com | www.1955pj.com | www.4737006.com | www.zr695.com | www.971551.com | www.666077.com | www.499680.com | www.89338c.com | www.sjgc9.com | www.18559t.com | www.bb888844.com | www.005575.com | www.394511.com | www.39500h.com | www.hg0555f.com | www.9646z.com | www.qifa888.com | www.901327.com | www.26878s.com | www.955ck.com | www.long8566.com | www.01885q.com | www.866309.com | www.41518m.com | www.dam666.com | www.153075.com | www.55080h.com | www.689253.com | www.78700f.com | www.dd75188.com | www.6939g.com | www.hd00080.com | www.202115.com | www.qmkl4.com | www.kb88dc13.com | www.60082020.com | www.109307.com | www.kkkk0136.com | www.6668888s.com | www.007009.com | www.50024r.com | www.66999f.com | www.6668888h.com | www.988824.com | www.66376x.com | www.37288d.com | www.78800c.com | www.693670.com | www.3890b.com | www.39533c.com | www.zycpw5.com | www.022193.com | www.wlb22.com | www.1489b.com | www.54968f.com | www.7782j.com | www.qxcp666.com | www.55388.com | www.65707b.com | www.18608146380.com | www.00880x.com | www.589879.com | www.cb7588.com | www.2255.com | www.550254.com | www.hcjt5.com | www.yh888c.com | www.672766.com | www.ya230.com | www.bet799365.com | www.771246.com | www.17wsz.com | www.760760a.com | www.644996.com | www.hm6788.com | www.wns18518888881.com | www.655061.com | www.c705.cc | www.8848hg2.com | www.373970.com | www.7860oo.com | www.bm1211.vip | www.50024m.com | www.lehu943.com | www.44252.com | www.679by.com | www.760760a.com | www.364877.com | www.p889988.com | www.551444.com | www.43818k.com | www.nn6199.com | www.769301.com | www.542yh.com | www.528505.com | www.81233q.com | www.3678rrr.com | www.590808.com | www.84898aabbb.com | www.7712.com | www.2kc.com | www.37570r.com | www.99788j.com | www.6906hh.com | www.djcp001.com | www.38200b.com | www.654189.com | www.zg16.com | www.5020777.com | www.26163h.com | www.zdj74.com | www.youxin9.cc | www.7454cc.com | www.710930.com | www.wzting5520.com | www.82894.com | www.cp3158.com | www.26616j.com | www.3552k.com | www.dc000999.com | www.26163s.com | www.68299455.com | www.50074b.com | www.4923i.com | www.87668x.com | www.livebf.com | www.36787g.com | www.stdaxing.com | www.26299f.com | www.qq3844.com | www.33588q.com | www.10877.com | www.26878n.com | www.8850w5.com | www.88858c.com | www.7384qqq.com | www.50080z.com | www.98777u.com | www.2875y.com | www.37433.com | www.cp8014.cc | www.sy679.net | www.tlc5500.com | www.810625.com | www.h88959.com | www.330587.com | www.l06966.com | www.62118d.com | www.43436z.com | www.5095c.com | www.hjc37.vip | www.caipiao33x.com | www.944229.com | www.55668ee.com | www.097968.com | www.rd7766.com | www.8667a.com | www.86697g.com | www.73055w.cc | www.660665.com | www.411777.com | www.00840q.com | www.3978z.com | www.66356r.com | www.855762.com | www.qile202.com | www.33997n.com | www.ctcp234.com | www.64566m.com | www.807979.com | www.tai288.com | www.76520n.com | www.231380.com | www.84898i.com | www.187380.com | www.jing7779.com | www.dhy2727.com | www.611506.com | www.yh7223.com | www.930xj.com | www.578668.com | www.ww3014.com | www.36788h.com | www.666011.com | www.jsdc9444.com | www.50026x.com | www.99844d.com | www.1341345.com | www.71233h.com | www.ylg881166.com | www.hg284.com | www.71233f.com | www.848678c.com | www.cq803.com | www.41518z.com | www.sl776.com | www.k47479.com | www.656zf.com | www.738742.com | www.ylam09.com | www.mg989.vip | www.128083.com | www.530.cc | www.hg515555.com | www.3479u.com | www.703270.com | www.167272.com | www.83636f.com | www.91233b.com | www.48234b.com | www.yl13561.com | www.am9987.com | www.77802q.com | www.ks3335.com | www.s2209.com | www.jx68.com | www.99677h.com | www.6140aa.com | www.pj00008888.com | www.a6995.com | www.77801a.com | www.26278b.com | www.288545.com | www.41779.app | www.07163h.com | www.809215.com | www.39919v.com | www.99990yh.com | www.2350j.com | www.361770.com | www.hy9847.com | www.h52266.com | www.42480.com | www.60123z.com | www.616144.com | www.5559045.com | www.vip1484.com | www.u3285.net | www.51515s.com | www.664043.com | www.66225144.com | www.ydzzapp.com | www.8706jj.com | www.662by.com | www.87668m.com | www.985175.com | www.28891z.com | www.1484g.com | www.zenghong1989.com | www.108ak.com | www.77114t.com | www.xinyc3.com | www.cp8789.com | www.yh888e.com | www.hg19938.com | www.6778d.com | www.60123w.com | www.343177.com | www.47118.com | www.77288mm.com | www.1479f.com | www.w865.net | www.a87445.com | www.022gs.cc | www.89894z.com | www.298730.com | www.809215.com | www.0761100.com | www.669226.com | www.091365.com | www.dhy6634.com | www.99029c.com | www.5109.cc | www.08588l.com | www.212632.com | www.682880.com | www.60259.cc | www.vns0998.net | www.63290t.com | www.999.ylcp7888.com | www.4912j.com | www.c5591111.cc | www.1823ccc.com | www.gyfc0.com | www.3479a.com | www.68689f.com | www.178736.com | www.568001.com | www.818646.com | www.803363.com | www.cp7777.com | www.thevns.net | www.js991992.com | www.21372226.com | www.a3a4.vip | www.88850w24.com | www.4323p.com | www.4288yy.com | www.7944999.com | www.0333js.com | www.565522u.com | www.883399n.com | www.358077.com | www.8124c.com | www.22222569.com | www.ag90921.com | www.bm5208.com | www.aa97066.com | www.xpj58088.com | www.656456.com | www.y9696.com | www.48488w.com | www.y186f.com | www.1326848.com | www.7605j.com | www.7885101.com | www.kkkk0010.com | www.7860qq.com | www.js889s.com | www.81002777.com | www.c559111.com | www.5565261.com | www.69589e.com | www.pj7598.com | www.1484p.com | www.04343b.com | www.www68666i.com | www.22113i.com | www.27363x.com | www.245508.com | www.43399.com | www.444fh.cc | www.888258.com | www.593477.com | www.318075.com | www.77114x.com | www.80065z.com | www.5095q.com | www.gczj5.com | www.709074.com | www.pj21599.com | www.hg7173.net | www.091365.com | www.www68666c.com | www.01885s.com | www.hy986.com | www.66049.com | www.545680.com | www.068617.com | www.bxcp3.com | www.022s.cc | www.wns123g.com | www.j773776.com | www.tyccp43.com | www.abdwc123.com | www.41186464.com | www.349584.com | www.407871.com | www.32123i.com | www.985jc.com | www.yaoshao168.com | www.777loo.com | www.zz3844.com | www.2371b.com | www.996732.com | www.666613c.com | www.455745.com | www.39500m.com | www.22czt.com | www.3050bb.com | www.7260a.com | www.999789vip.com | www.c73.vip | www.266991.com | www.16878p.com | www.24107s.com | www.qifa613.com | www.3775e.com | www.62220.com | www.178125.com | www.cll168.com | www.1389uu.com | www.80800j.com | www.sb0411.com | www.582993.com | www.50054z.com | www.7860hh.com | www.686890.com | www.i3122.com | www.580671.com | www.50732m.com | www.y2272.com | www.38135q.com | www.9795666.com | www.530629.com | www.33598f.com | www.2714943196.com | www.019970.com | www.3494.com | www.xinyc1.com | www.27czj.com | www.k3mmm.com | www.9846j.com | www.587989.com | www.cll168.com | www.h88892.com | www.18390077.com | www.578393.com | www.3416e.com | www.8777q.com | www.2041ss.com | www.599464.com | www.3933b.cc | www.lo699.com | www.477328.com | www.234827.com | www.w603.com | www.3678jjj.com | www.f42.cc | www.33997v.com | www.df8kk.com | www.3775c.com | www.558429.com | www.wo41.com | www.99830j.com | www.mh7749.com | www.75679.com | www.6598vip.com | www.73055w.com | www.77803e.com | www.17363972162.com | www.f36531.com | www.550194.com | www.csgc9.com | www.999.ylcp3888.com | www.854766.com | www.1555hc.com | www.355887.com | www.912183.com | www.1035k.com | www.3566tt.com | www.972283.com | www.3136aa.com | www.88877l.com | www.luck887.com | www.585hc.com | www.58444cp.com | www.668566.com | www.c166.vip | www.269585.com | www.330836.com | www.jinsha715.com | www.9229js.com | www.96386x.com | www.25288y.com | www.222111c.com | www.54968g.com | www.151032.com | www.918681.com | www.ck09.com | www.55a32.com | www.lcw997.com | www.954321t.com | www.123883.com | www.21202w.com | www.zr695.com | www.544646.com | www.1123ww.com | www.710169.com | www.33358c.com | www.911000l.com | www.550346.com | www.jia14793935807.com | www.c49889.com | www.15355m.com | www.test222.com | www.276081.com | www.feicai0373.com | www.343335.com | www.df94.com | www.06088a.com | www.61233z.com | www.7681h.com | www.282263.com | www.z773776.com | www.tt08.com | www.dhy4545.com | www.1119045.com | www.23040.com | www.99775c.com | www.78949h.com | www.3311sun.com | www.496918.com | www.16789b.com | www.935257.com | www.tlc5100.com | www.778666.com | www.01885i.com | www.ctxcp300.com | www.44qxc.com | www.990060033.com | www.33112c.com | www.456916.com | www.73166g.com | www.w626666.com | www.43131r.com | www.7345y.com | www.50732e.com | www.00829y.com | www.50054g.com | www.902425.com | www.32123d.com | www.444068.cc | www.91233hh.com | www.xx2229.com | www.54400q.com | www.9216h.com | www.8667e.com | www.77288qq.com | www.910xj.com | www.34445b.com | www.am5432.com | www.466826.com | www.8124a.com | www.926576.com | www.csj5800.com | www.508680.com | www.d8502.com | www.99638g.com | www.8488yd.com | www.50080g.com | www.364128.com | www.qmfc6.com | www.49009c.com | www.jsvip123.com | www.599260.com | www.qifa516.com | www.60108g.com | www.fhyl58.net | www.9889hc.com | www.bb125.com | www.v2859.com | www.499428.com | www.829222.com | www.50051h.com | www.8649911.com | www.1992535.com | www.753956.com | www.zunlonghui6.com | www.50052c.com | www.88839w.com | www.43012f.com | www.850533.com | www.55676i.com | www.33588q.com | www.hg75005.com | www.88188e.cc | www.627792.com | www.007272.com | www.91091.cc | www.lhc9.com | www.ddw789.com | www.50064y.com | www.5804m.com | www.520168djkk.com | www.335243.com | www.86450.com | www.c5128.com | www.815055.com | www.88877j.com | www.5095m.com | www.wm888.com | www.longfa321.com | www.77210j.com | www.lyc555.com | www.999js9.com | www.29277j.com | www.806727.com | www.fy595.com | www.33588d.com | www.js29.com | www.gcw37.com | www.21202p.com | www.92223.com | www.ddc788.com | www.76520j.com | www.92242.com | www.j47479.com | www.2875h.com | www.914907.com | www.7345p.com | www.cccc0085.com | www.368518.com | www.59199s.com | www.pj21998.com | www.36788k.com | www.8703.com | www.003283.com | www.sjgc4.com | www.377591.com | www.037-6.com | www.444js4.com | www.29277w.com | www.911209.com | www.7894j.com | www.83356a.com | www.41518j.com | www.69005.com | www.xpjvip-8.com | www.hg7784.com | www.97655j.com | www.455111.com | www.40002a.com | www.cb5388.com | www.087079.com | www.fhc01.com | www.v15560.com | www.8072229.com | www.71399f.com | www.555523.com | www.81866u.com | www.28577g.vip | www.75538d.com | www.808712.com | www.55080o.com | www.678js666.com | www.axc4.com | www.83993z.com | www.654455.com | www.ylam05.com | www.h678992.com | www.9356k.com | www.xcw866.com | www.3663yh.com | www.x6098.com | www.135520q.com | www.9818p.cc | www.351376.com | www.222111b.com | www.6668888i.com | www.57398.am | www.888xm.cc | www.bxcp3.com | www.1997.com | www.18391199.com | www.cp001l.com | www.21819b.com | www.26878j.com | www.312012.com | www.26278a.com | www.y44447.com | www.0267w.com | www.749417.com | www.58699.cc | www.101129.com | www.934277.com | www.59677n.com | www.00829i.com | www.22557x.com | www.dhy1511.com | www.26163c.com | www.163090.com | www.902271.com | www.03369a.com | www.647586.com | www.781492.com | www.am769.com | www.ya638.com | www.509866.com | www.251750.com | www.926280.com | www.7384iii.com | www.39919o.com | www.x33r.vip | www.ddc8888.com | www.v7415.com | www.080wy.com | www.68682f.com | www.106560.com | www.605733.com | www.deshunsy.com | www.op666kai.com | www.d67783.com | www.zbb55.com | www.781424.com | www.dw8886.com | www.tlc5900.com | www.ch1018.com | www.2109g.com | www.60123g.com | www.53900l.com | www.196501.com | www.556346.com | www.844689.com | www.113342.com | www.9995.tw | www.57803.com | www.77288aa.com | www.2257017.com | www.88850a.com | www.99830w.com | www.qwe520.com | www.678js222.com | www.997781.com | www.a7249.com | www.37377b.com | www.5817006.cc | www.xpj891.com | www.c5839.com | www.102ak.com | www.3126s.com | www.00840y.com | www.50024k.com | www.52303j.com | www.77802r.com | www.81678h.com | www.99677y.com | www.21202k.com | www.08588q.com | www.99638b.com | www.81233q.com | www.71399k.com | www.54400j.com | www.35918g.com | www.26199.com | www.3479f.com | www.022qh.cc | www.bxcp3333.com | www.hycb8.com | www.am6543.com | www.48488u.com | www.hg888118.com | www.1596n.com | www.666698b.com | www.u4065.com | www.565522s.com | www.long8775.com | www.9646l.com | www.xpj0123456789.com | www.zdj74.com | www.258608.com | www.hg9665.co | www.1zjccp5.com | www.885050.com | www.962387.com | www.609815.com | www.234287.com | www.50080k.com | www.35155y.com | www.078wy.com | www.vnsrcasino9.com | www.ysl5201314.com | www.7877122.com | www.5566yh.com | www.4323v.com | www.3777221.com | www.w9.cc | www.76755.co | www.xinyc3.com | www.87668j.com | www.50064x.com | www.dqz6.com | www.bygj24.com | www.8777i.com | www.xpj5590.com | www.65188k.com | www.62775500.com | www.979683.com | www.407872.com | www.50788l.com | www.3479d.com | www.8473o.com | www.yingjia777.com | www.6939t.com | www.55080t.com | www.13622a.com | www.586005.com | www.50989f.com | www.636by.com | www.ke88888888.com | www.qxcp333.com | www.31788c.com | www.280.cc | www.yc7701.com |